Multisite phosphorylation determines the formation of Ska–Ndc80 macro-complexes that are essential for chromosome segregation during mitosis
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چکیده
منابع مشابه
Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis
Microtubule nucleation is highly regulated during the eukaryotic cell cycle, but the underlying molecular mechanisms are largely unknown. During mitosis in fission yeast Schizosaccharomyces pombe, cytoplasmic microtubule nucleation ceases simultaneously with intranuclear mitotic spindle assembly. Cytoplasmic nucleation depends on the Mto1/2 complex, which binds and activates the γ-tubulin compl...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2020
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e19-10-0569